Time-resolved transcriptomics in neural stem cells identifies a v-ATPase/Notch regulatory loop
نویسندگان
چکیده
منابع مشابه
A Regulatory Transcriptional Loop Controls Proliferation and Differentiation in Drosophila Neural Stem Cells
Neurogenesis is initiated by a set of basic Helix-Loop-Helix (bHLH) transcription factors that specify neural progenitors and allow them to generate neurons in multiple rounds of asymmetric cell division. The Drosophila Daughterless (Da) protein and its mammalian counterparts (E12/E47) act as heterodimerization factors for proneural genes and are therefore critically required for neurogenesis. ...
متن کاملCompromise of Multiple Time-Resolved Transcriptomics Experiments Identifies Tightly Regulated Functions
With the advent of high-throughput technologies for data acquisition from different components (i.e., genes, proteins, and metabolites) of a given biological system, generation of hypotheses, and biological interpretations based on multivariate data sets become increasingly important. These technologies allow for simultaneous gathering of data from the same biological components under different...
متن کاملP111: Effect of Human Neural Stem Cells on Neural Hyperactivity in Kindeling Rat Models
The excessive electrical activity of neurons is reported in many diseases including: Parkinson's disease, Alzheimer's disease, and Epilepsy. Electrical overactivity in hippocampus accelerates the depletion of neural stem cell (NSC) and impairs the neurogenesis in hippocampus. It is believed that neurogenesis in hippocampus improves the cognitive functions. In this experiment, we use kindled mod...
متن کاملTranscriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology
Neural stem cells (NSCs) reside in a hypoxic microenvironment within the brain. However, the crucial transcription factors (TFs) that regulate NSC biology under physiologic hypoxia are poorly understood. Here we have performed gene set enrichment analysis (GSEA) of microarray datasets from hypoxic versus normoxic NSCs with the aim of identifying pathways and TFs that are activated under oxygen ...
متن کاملIn Vitro Differentiation of Neural Stem Cells into Noradrenergic-Like Cells
Neural stem cells (NSCs) as a heterogeneous multipotent and self- renewal population are found in different areas in the developing mammalian nervous system, as well as the sub-ventricular zone (SVZ) and the hippocampus of the adult brain. NSCs can give rise to neurons, astrocytes and oligodendrocytes. The aim of this study was to differentiate neural stem cells into noradrenergic–like cells in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2018
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201711167